Ivan Soltesz

Stanford University


Towards a complete description of the circuitry underlying sharp wave-mediated memory replay
Our team is making the first attempt to fully understand a cognitively important event, called memory replay during sharp-wave ripples, in terms of the detailed properties of the brain cells involved. We employ large-scale recording technologies to study and manipulate identified cell types in the behaving animal and construct the first full-scale computational model of the brain area

that produces the memory replay called the hippocampus in which every cell is explicitly simulated in supercomputers. These powerful new approaches are likely to yield major insights into the principles by which the interactions of neurons give rise to cognitive function, with important implications for memory disorders and cognitive comorbidities in a variety of neuropsychiatric and neurological disorders. Supported by the BRAIN Initiative U19 NS104590.